Approfondimenti scientifici
Pregnancy and Blood Pressure Regulation: Pathways to Balance and Health for Mother and Baby
Hypertensive disorders represent a significant component of maternal-fetal medicine, encompassing a heterogeneous group of conditions that can profoundly influence the course of pregnancy and maternal and fetal outcomes.

The main clinical conditions are commonly classified as follows:
Pre-existing Chronic Hypertension
This is defined as a blood pressure of ≥140/90 mmHg present before pregnancy or diagnosed before the 20th week of gestation. With appropriate specialist monitoring, favorable maternal and fetal outcomes can be achieved. Management includes:
- Antihypertensive therapies compatible with pregnancy and breastfeeding.
- Clinical and laboratory surveillance (e.g., blood tests, echocardiography).
- Low-dose aspirin (60–150 mg/day), recommended to reduce the risk of preeclampsia (Rolnik et al., 2017).
- Ultrasound monitoring of fetal growth and Doppler velocimetry starting from the 28th week of gestation.
Gestational Hypertension
Diagnosed after the 20th week of gestation in previously normotensive women, gestational hypertension is the most common form of hypertension during pregnancy. Its course may vary, with possible postpartum resolution or progression to preeclampsia or previously unrecognized chronic hypertension. Careful blood pressure monitoring, combined with the assessment of proteinuria (using the protein-to-creatinine ratio or a 24-hour urine collection), forms the diagnostic basis for distinguishing gestational hypertension from preeclampsia, which is characterized by systemic endothelial dysfunction and multi-organ involvement (American College of Obstetricians and Gynecologists, 2020).
Risk factors for the development of gestational hypertension and preeclampsia include:
- First pregnancy (primiparity)
- Extreme maternal age (<18 or >40 years)
- Family history
- Obesity
- Pre-existing diabetes
- Chronic kidney disease
- Twin or multiple pregnancies
Individualized counselling and education aimed at the early recognition of symptoms such as persistent headache, visual disturbances, epigastric pain, and reduced fetal movements are essential for timely intervention and optimal management.
Lifestyle interventions—including weight management, regular physical activity, and a low-sodium diet—help maintain blood pressure within physiological ranges, contributing to an optimal intrauterine environment and improved maternal health (Magee et al., 2014).
Preeclampsia and Eclampsia Syndrome
Preeclampsia is a hypertensive complication of pregnancy affecting approximately 8% of pregnant women (WHO, 2022). It typically develops after the 20th week of gestation, presenting with elevated blood pressure and the presence of protein in the urine, and may have significant consequences for both the mother and the fetus. However, in recent years, scientific advances have led to substantial improvements in early diagnosis, treatment, and prevention.
Eclampsia is a condition that may occur during pregnancy—usually in the later stages—or shortly after delivery, and is characterized by seizures in women with preeclampsia. Although it may appear alarming, eclampsia is now well understood, treatable, and successfully managed in the vast majority of cases thanks to modern medicine. Advances in early diagnosis, prevention, and multidisciplinary management have significantly improved clinical outcomes.
Prevention Strategies
Education focused on preventive care is fundamental. Key elements include:
- A balanced diet: rich in fruits, vegetables, and whole grains, low in sodium, and ensuring adequate calcium and magnesium intake.
- Moderate physical activity: such as walking or prenatal yoga, which improves endothelial function and blood pressure control.
- Weight management: maintaining appropriate gestational weight gain according to the Institute of Medicine (IOM) guidelines.
- Psychological support: essential for reducing anxiety and stress, both of which are associated with poorer blood pressure control.
Psychological Well-being in Hypertensive Pregnancy
In pregnancies complicated by hypertension, the expectant mother may experience a sense of losing control over her body, diminished perceived self-efficacy, and increasing anxiety regarding her own health and that of her unborn child. These experiences, often accompanied by feelings of inadequacy, fear of adverse pregnancy outcomes, and, at times, emotional detachment as a defense mechanism, may interfere with the natural development of maternal-fetal bonding, the early emotional connection that begins to form during pregnancy.
Within this context, interventions aimed at strengthening maternal-fetal bonding—such as perinatal mindfulness, prenatal communication with the fetus, and positive visualization techniques—have proven particularly effective. These practices help mothers regain a sense of centrality and active participation in their pregnancy journey, fostering emotional continuity with their baby while reducing the sense of passivity and medicalization imposed by the clinical condition.
Positive visualization is a mind-body technique based on the use of mental imagery to evoke positive emotions, promote physiological relaxation, and strengthen emotional self-regulation. During pregnancy, particularly in vulnerable situations such as hypertension, it can pursue several therapeutic and relational goals:
- Strengthening the mother–baby bond: imagining the baby’s face, movements, or state of well-being promotes the development of an early emotional relationship, even in high-risk pregnancies.
- Reducing anxiety: visualizing peaceful environments or reassuring experiences—such as a calm birth or the tenderness of immediate skin-to-skin contact—helps modulate the activity of the limbic system, particularly the amygdala, while enhancing vagal tone, thereby promoting relaxation.
- Promoting self-efficacy: imagining scenarios of health, strength, and well-being reinforces maternal confidence and reduces the negative psychological impact of a hypertension diagnosis.
These techniques can be practiced daily, even for short periods (10–15 minutes), either under the guidance of healthcare professionals or through structured audio recordings. They represent an important tool for promoting perinatal mental health.
Finally, both the mode and timing of delivery should be carefully individualized according to the mother’s clinical condition, avoiding early induction of labor in the absence of medical indications and, whenever possible, supporting vaginal birth. This approach, combined with an evidence-based multidisciplinary model of care, ensures comprehensive and integrated management of hypertensive disorders during pregnancy. It maximizes maternal and fetal well-being while recognizing pregnancy—even when complicated by disease—as a unique opportunity to promote the long-term health of both mother and child.
American College of Obstetricians and Gynecologists. (2020). Hypertension in Pregnancy. ACOG Practice Bulletin No. 222. Obstetrics & Gynecology, 135(6), e237-e260
Brown, M. A., Magee, L. A., Kenny, L. C., et al. (2018). Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International Practice. Hypertension, 72(1), 24-43
Magee, L. A., Pels, A., Helewa, M., et al. (2014). Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. Pregnancy Hypertension, 4(2), 105-145
Rana, S., Lemoine, E., Granger, J., & Karumanchi, S. A. (2019). Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circulation Research, 124(7), 1094-1112.
Rolnik, D. L., Wright, D., Poon, L. C., et al. (2017). Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia. New England Journal of Medicine, 377(7), 613-622
Sibai, B. M. (2019). Diagnosis, prevention and management of eclampsia. American Journal of Obstetrics and Gynecology, 226(5), S99-S109
